F1-ispinesib

SKU: orb3174189

Description

F1-ispinesib is a heterobifunctional F1 autophagy degrader, comprising an RNA binding fragment (F1) and the LC3B ligand Ispinesib. It induces the degradation of COL15A1 mRNA through an LC3B-dependent macroautophagy mechanism. Additionally, F1-ispinesib inhibits the proliferation of human aortic smooth muscle cells while enhancing their migration.

Key Properties

• Target: Autophagy

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Autophagy