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F1-ispinesib

SKU: orb3174189

Description

F1-ispinesib is a heterobifunctional F1 autophagy degrader, comprising an RNA binding fragment (F1) and the LC3B ligand Ispinesib. It induces the degradation of COL15A1 mRNA through an LC3B-dependent macroautophagy mechanism. Additionally, F1-ispinesib inhibits the proliferation of human aortic smooth muscle cells while enhancing their migration.

Research Area

Cell Biology

Images & Validation

Key Properties

TargetAutophagy

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information