F-15599

SKU: orb1299953

Description

F-15599 is a potent and highly selective G-protein biased agonist of the 5-HT1A receptor, exhibiting a binding affinity (Ki) of 3.4 nM. Its functional selectivity makes it a valuable research tool for investigating serotonin signaling in neuropsychiatric disorders, supporting both in vitro binding studies and in vivo behavioral experiments.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 635323-95-4
• MW: 394.85
• Purity: 98.72% (May vary between batches)
• Formula: C₁₉H₂₁ClF₂N₄O
• SMILES: Cc1cnc(CNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
• Target: 5-HT Receptor
• Solubility: DMSO:22.5 mg/mL (56.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.07 mM)

Bioactivity

• Target IC50:
  5-HT1A:3.4 nM(ki)
• In Vivo:
  F-15599 exerted very potent (ID50 = 0.095 and 0.0059 mg/kg, respectively) anti-aggressive effects in male WTG rats. At 4.5-fold higher dose ranges, the anti-aggressive effects were accompanied by concomitant motor inactivity and/or reduction of social engagement. Pretreatment with WAY-100635 counteracted the behavioural effects of both agonists.
• Animal Research:
  F-15599 agonists were acutely administered intraperitoneally in aggressive resident male WTG rats confronting an intruder.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-hydroxytryptamine Receptor, 5HTReceptor, 5-HT1A, 5HT Receptor, 5-HT Receptor, inhibit, NLX101, NLX-101, NLX 101, Inhibitor, F15599, F-15599, F 15599, Serotonin Receptor

Compound Identifiers

PubChem CID

11741361