F-14512 Hydrochloride

SKU: orb3177611

Description

F-14512 Hydrochloride is a highly potent and tumor-selective inhibitor of DNA topoisomerase II. F-14512 Hydrochloride enhances topoisomerase II inhibition through the high affinity of polyamines for DNA, enabling selective cellular uptake. It exhibits significant cytotoxicity against tumor cells with high PTS activity and induces DNA damage and apoptosis. F-14512 Hydrochloride has demonstrated potent antitumor activity in various tumor models, including MX-1 breast cancer, HL-60 leukemia, and A2780 ovarian cancer. F-14512 Hydrochloride can be used in cancer treatment research.

Key Properties

• CAS Number: 866874-39-7
• MW: 787.60
• Formula: C₃₃H₅₁Cl₄N₅O₈
• SMILES: O=C1[C@]2([H])[C@H](C3=CC(OC)=C(C(OC)=C3)O)C4=CC(OCO5)=C5C=C4[C@H]([C@@]2([H])CO1)NC(CNCCCNCCCCNCCCN)=O.Cl.Cl.Cl.Cl
• Target: Topoisomerase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Topoisomerase