F-1

SKU: orb1309684

Description

F-1 is a potent dual ALK/ROS1 inhibitor with IC50 values of 2.1 nM (ALKWT), 2.3 nM (ROS1WT), 1.3 nM (ALKL1196M), and 3.9 nM (ALKG1202R). It effectively suppresses phospho-ALK and downstream signaling, making it a valuable tool compound for in vitro and in vivo cancer research targeting ALK and ROS1-driven malignancies.

Research Area

Cardiovascular Research, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2244775-31-1
• MW: 519.02
• Purity: 99.50% (May vary between batches)
• Formula: C₂₂H₂₇ClN₈O₃S
• SMILES: COc1nc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCN(C)CC1
• Target: ROS Kinase,ALK,ROS
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.71 mM);DMSO:100 mg/mL (192.67 mM)

Bioactivity

• Target IC50:
  ALK (L1196M):1.3 nM|ROS1 (WT):2.3 nM|ALK (G1202R):3.9 nM|ALK (WT):2.1 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, F 1, F-1, F1, Anaplastic lymphoma kinase (ALK), Anaplastic lymphoma kinase, ALK, ALK tyrosine kinase receptor, Cluster of differentiation 246, CD246, ROS1, ROSKinase, ROS Kinase

Compound Identifiers

PubChem CID

138454747