EZH2/HSP90-IN-29

SKU: orb3027401

Description

EZH2/HSP90-IN-29 is a potent dual inhibitor of EZH2 and HSP90, with IC50 values of 6.29 nM and 60.1 nM, respectively. It induces cell cycle arrest at the M phase, promotes the expression of genes related to apoptosis/necrosis, and inhibits reactive oxygen species (ROS) catabolism. This compound can cross the blood-brain barrier, making it a promising and easily manageable candidate for glioblastoma (GBM) research.

Key Properties

• CAS Number: 3033571-35-3
• MW: 680.83
• Formula: C₄₀H₄₈N₄O₆
• SMILES: O=C(NCC=1C(=O)NC(=CC1C)C)C=2C=C(C=C(C2C)N(CC)C3CCOCC3)C=4C=CC=C(C4)N(C(=O)C=5C=C(C(O)=CC5O)C(C)C)C
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Others