Ezetimibe ketone

SKU: orb1992861

Description

Ezetimibe ketone (EZM-K), an active metabolite of Ezetimibe, exhibits antioxidant properties by reducing H2O2-induced ROS and apoptosis in renal NRK-52E cells through the upregulation of the Nrf2/HO-1 pathway. This small molecule is a valuable research tool for investigating oxidative stress mechanisms in vitro and exploring potential nephroprotective applications.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 191330-56-0
• MW: 407.41
• Formula: C₂₄H₁₉F₂NO₃
• SMILES: C(CC(=O)C1=CC=C(F)C=C1)[C@@H]2[C@](N(C2=O)C3=CC=C(F)C=C3)(C4=CC=C(O)C=C4)[H]
• Target: NPC1L1|||Nrf2
• Solubility: DMSO:80 mg/mL (196.36 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.91 mM)

Bioactivity

• In Vivo:
  In rat RIRI models, pretreatment with Ezetimibe ketone activated Nrf2/HO-1 signaling pathway, inhibited renal tubule injury and inflammation, and improved renal function.
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• In Vitro:
  Ezetimibe ketone alleviates H2O2-induced apoptosis and reactive oxygen species (ROS) production in NRK-52E cells, and upregulates Nrf2 and HO-1 levels.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EZM-K, Ezetimibe ketone, NPC1L1, Nrf2

Compound Identifiers

PubChem CID

9801494