(E/Z)-Squalene

SKU: orb1744042

Description

(E/Z)-Squalene modulates intracellular reactive oxygen species (ROS) generation, triggering concentration- and time-dependent apoptosis and necrosis. It accumulates in hepatic tissue, where it demonstrates lipid-lowering effects on cholesterol and triglycerides. This compound is utilized in research fields such as lipid metabolism, hepatotoxicity, and cell death mechanisms in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 7683-64-9
• MW: 410.72
• Purity: 98.15% (May vary between batches)
• Formula: C₃₀H₅₀
• SMILES: C(CC(=CCCC=C(CCC=C(CCC=C(C)C)C)C)C)C=C(CCC=C(C)C)C
• Target: Apoptosis,ROS
• Solubility: DMSO:50 mg/mL (121.74 mM)

Bioactivity

• In Vitro:
  (E/Z)-Squalene (0-50 μM) in human breast epithelial cells (MCF10A) decreases intracellular ROS levels, thereby preventing H2O2-induced oxidative damage and protecting against DNA oxidative damage.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ROS, (E/Z)-AddaVax, (E/Z)-Squalene, (E/Z)-Super Squalene, Apoptosis

Compound Identifiers

PubChem CID

1105