(E/Z)-IT-603

SKU: orb1298623

Description

(E/Z)-IT-603 is a cell-permeable small molecule that acts as a direct and reversible c-Rel inhibitor with an IC50 of 3 µM. It disrupts c-Rel's DNA binding and transcriptional activity by inducing a conformational change. This inhibitor is a valuable tool for studying NF-κB signaling in immunological and oncological research, applicable in both cellular and animal models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 292168-90-2
• MW: 329.17
• Purity: 99.35% (May vary between batches)
• Formula: C₁₁H₉BrN₂O₃S
• SMILES: COc1cc(Br)cc(\C=C2\NC(=S)NC2=O)c1O
• Target: NF-κB
• Solubility: DMSO:27.5 mg/mL (83.54 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

c-Rel, disease, (E/Z) IT 603, (E/Z)-IT 603, (E/Z)IT603, (E/Z)-IT603, (E/Z)-IT-603, Nuclear factor-κB, Nuclear factor-kappaB, NF-κB, NFκB, NF-kB, NFkB, immunomodulatory, IT603, IT-603, IT 603, inhibit, Inhibitor, GVHD, therapy

Compound Identifiers

PubChem CID

840180