(E/Z)-E64FC26

SKU: orb1691036

Description

(E/Z)-E64FC26 is a potent, pan-PDI family inhibitor targeting PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. It exhibits antitumor activity and is a valuable research tool for studying myeloma, with applications in both in vitro biochemical assays and in vivo xenograft models.

Research Area

Cell Biology

Key Properties

• CAS Number: 2285446-67-3
• MW: 340.38
• Purity: 98.23% (May vary between batches)
• Formula: C₁₉H₂₃F₃O₂
• SMILES: FC(F)(F)C1=CC(=CCCCCCCCC)C=2C=C(O)C(O)=CC21
• Target: Apoptosis
• Solubility: DMSO:80 mg/mL (235.03 mM)

Bioactivity

• Target IC50:
  PDIA3:20.9 μM|PDIA1:1.9 μM|TXNDC5:16.3 μM|PDIA6:25.4 μM|PDIA4:25.9 μM
• In Vitro:
  (E/Z)-E64FC26 is an effective broad-spectrum inhibitor of the protein disulfide isomerase (PDI) family, with half-maximal inhibitory concentrations (IC50) of 1.9, 20.9, 25.9, 16.3, and 25.4 μM for PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. Additionally, (E/Z)-E64FC26 demonstrates anti-myeloma activity.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(E/Z)E64FC26, (E/Z)-E64FC26, (E/Z)-E-64FC26, (E/Z) E64FC26, Apoptosis, PDI

Compound Identifiers

PubChem CID

155891120