(E/Z)-BCI

SKU: orb1309724

Description

(E/E)-BCI (NSC-150117) is a DUSP6 inhibitor with anti-inflammatory activity. It suppresses LPS-induced inflammation and oxidative stress in macrophages by inhibiting the NF-κB pathway and activating Nrf2 signaling. This compound is a useful research tool for studying inflammation, redox biology, and macrophage function in vitro.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 15982-84-0
• MW: 317.42
• Purity: 99.94% (May vary between batches)
• Formula: C₂₂H₂₃NO
• SMILES: O=C1C(=Cc2ccccc2)C(NC2CCCCC2)c2ccccc12
• Target: Phosphatase,Apoptosis
• Solubility: Ethanol:20 mg/mL (63.01 mM);DMSO:50 mg/mL (157.52 mM)

Bioactivity

• In Vivo:
  (E/Z)-BCI hydrochloride treatment enhances cisplatin efficacy in PDX models.
• In Vitro:
  (E/Z)-BCI hydrochloride (2-10 μM; 72 hours) significantly reduces cell viability in a time and dose-dependent manner in gastric epithelial cell GES1, GC cell lines, and AGS cell lines. Additionally, (E/Z)-BCI hydrochloride (0.5-4 μM; 24 hours) significantly inhibits DUSP6 expression in LPS-activated macrophages, while also inhibiting cell proliferation, migration, and invasion in a receptor-independent manner, enhancing Cisplatin (CDDP) cytotoxicity, and promoting apoptosis in GC cells. Moreover, (E/Z)-BCI hydrochloride (0.5-2 μM; 24 hours) significantly suppresses IL-1β, TNF-α, and IL-6 mRNA expression in LPS-activated macrophages, decreases ROS production, and activates the Nrf2 pathway.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-inflammatory, Apoptosis, (E/Z) BCI, (E/Z)BCI, (E/Z)-BCI, DUSP6, ERK, death, gastric cancer, Inhibitor, inhibit, LPS, NSC150117, NSC-150117, NSC 150117, Nrf2, NF-κB, ROS, Phosphatase

Compound Identifiers

PubChem CID

422981