Exendin-4

SKU: orb1303499

Description

Exendin-4

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 141758-74-9
• MW: 4186.57
• Purity: 99.78%
• Formula: C₁₈₄H₂₈₂N₅₀O₆₀S
• SMILES: CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O
• Target: Glucagon Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (0.48 mM);DMSO:10 mM;H2O:1.23 mg/mL (0.29 mM)

Bioactivity

• Target IC50:
  GLP1:3.22 nM
• In Vivo:
  In ob/ob mice the treatment of exendin-4 improve serum ALT and reduce serum glucose, Insulin levels and calculated HOMA scores compared with control. in the final 4 weeks o the study period, exendin-4-treated ob/ob mice sustain an obvious reduction in the net weight gai . Animals treated with exendin-4 have more pyknotic nuclei, more pancreatic acinar inflammation and weigh significantly less than control rat. Exenatide leads to dose-dependent relaxation of rat thoracic aorta, which is evoked vi the GLP-1 receptor and is mediated mainly by H2S but also by CO and N .
• In Vitro:
  In HUVECs, exendin-4 dose-dependently significantly increases NO production, eNOS phosphorylation and GTPCH1 leve. Exendin-4 shows cytotoxic effects to MCF-7 breast cancer cells IC50 5 μM) at 48 hours.

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Exenatide, Exendin 4, Exendin4, Exendin-4, Glucagon Receptor, glucagon-like peptide-1 receptor, GlucagonReceptor, 141732-76-5

Compound Identifiers

PubChem CID

45588096