Exarafenib

SKU: orb1686395

Description

Exarafenib (RAF/KIN_2787) is an orally bioavailable, pan-RAF inhibitor that suppresses the MAPK signaling pathway, demonstrating antitumor efficacy. It is utilized in cancer research for investigating RAF-driven malignancies in both cellular and animal models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2639957-39-2
• MW: 521.58
• Purity: 99.84% (May vary between batches)
• Formula: C₂₆H₃₄F₃N₅O₃
• SMILES: C[C@H](CO)Nc1cc(cc(n1)N1CCOCC1)-c1cc(NC(=O)N2CC[C@@H](CC(F)(F)F)C2)ccc1C
• Target: Raf,p38 MAPK
• Solubility: DMSO:50 mg/mL (95.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.83 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Exarafenib, p38MAPK, p38 MAPK, RAF/KIN_2787

Compound Identifiers

PubChem CID

156297592