EVT0185

SKU: orb3136817

Description

EVT0185 is an orally active ATP citrate lyase (ACLY) inhibitor. In the liver, it is converted by SLC27A2 into a CoA thioester, which interacts with the CoA binding site of ACLY. EVT0185-CoA inhibits ACLY activity with an IC50 of 2.5 μM. It mimics the immune and antitumor effects seen with ACLY gene deletion. Additionally, EVT0185 elevates levels of tumor-infiltrating B cells and the chemokine CXCL13. It is applicable in cancer research, including hepatocellular carcinoma (HCC).

Research Area

Metabolism Research

Key Properties

• CAS Number: 2588489-03-4
• MW: 362.50
• Formula: C₂₂H₃₄O₄
• SMILES: O=C(O)C(C)(C)CCCCC1=CC=C(C=C1)CCCCC(C(=O)O)(C)C
• Target: ATP Citrate Lyase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ATP Citrate Lyase