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Everafenib

SKU: orb1686830

Description

Everafenib is a brain-penetrant BRAF inhibitor that potently suppresses the MAPK pathway. It demonstrates superior in vitro potency against V600E BRAF melanoma cell lines compared to dabrafenib and vemurafenib and has shown efficacy in extending survival in intracranial melanoma mouse models.

Research Area

Signal Transduction

Images & Validation

Key Properties

MW484.01
FormulaC20H23ClFN5O2S2
TargetRaf,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

Everafenib (orb1686830)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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