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Eurycomalactone
Catalog Number: orb1219404
| Catalog Number | orb1219404 |
|---|---|
| Category | Small Molecules |
| Description | Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-induced degradation of IκBα or the phosphorylation of IKKα/β and IκBα. |
| Target | NF-κB|Antifection |
| Purity | >98% (HPLC) |
| MW | 348.4 |
| CAS Number | 23062-24-0 |
| Formula | C19H24O6 |
| Storage | Storage temperature: -20°C. Stability: ≥ 2 years |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
Eurycomalactone [orb1297377]
99.87%
23062-24-0
348.39
C19H24O6
5 mg, 1 mg, 10 mg, 50 mg, 25 mg, 1 ml x 10 mM (in DMSO)
For example, if the dosage of your experiment is 10mg/kg, the weight of each animal is 50g, and the volume of the dosing is 100μL, then the working solution concentration of your experiment is 5mg/mL. If the formula you used is 5% DMSO+ 30% PEG300+ 5% Tween 80 + 60% Saline/PBS/ddH2O, the preparation method is as follows:
Mother liquor preparation method: 5mg of drug dissolved in 100μL DMSO (mother liquor concentration is 50mg/mL). Preparation method of in vivo formulation: For 1mL of working solution preparation, take 50μL of DMSO mother liquor, add 300 μL of PEG300 to mix well and clarify, then add 50μL of Tween-80 to mix well and clarify, and finally add 600μL of Saline/PBS/ddH2O to mix well and clarify.Note:
- For Reference Only. Please choose the appropriate dissolution protocol according to your experimental animal and administration method.
- We suggest that in cell experiments, the final concentration of DMSO is not more than 0.1%, in animal experiments, for healthy mice, the final concentration of DMSO is not more than 10%; For nude or frail mice, the final concentration of DMSO is not more than 2%.
