Euphorbia Factor L2

SKU: orb1301480

Description

This product, Euphorbia Factor L2, is a bioactive diterpenoid that inhibits NF-κB activation. It has demonstrated efficacy in reducing inflammation and injury in LPS-induced acute lung injury models, making it a valuable tool for research in pulmonary inflammation and innate immunity.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 218916-51-9
• MW: 642.73
• Purity: 99.96% (May vary between batches)
• Formula: C₃₈H₄₂O₉
• SMILES: [H][C@]12C[C@@H](OC(=O)c3ccccc3)C(=C)[C@H](OC(C)=O)[C@@]3([H])[C@@H](OC(=O)c4ccccc4)[C@@H](C)C[C@]3(OC(C)=O)C(=O)\C(C)=C\[C@@]1([H])C2(C)C
• Target: NF-κB,Apoptosis
• Solubility: 10% DMSO+90% Corn Oil:1 mg/mL (1.56 mM);DMSO:12 mg/mL (18.67 mM)

Bioactivity

• In Vivo:
  Euphorbia factor L2 (EFL2) on LPS-induced ALI in mice, where EFL2 attenuated pathological alterations in the lung and improved survival. Significant suppression of the recruitment and transmigration of inflammatory cells, specifically neutrophils, by 40 mg/kg of EFL2 was observed. EFL2 exerted potent anti-inflammatory effects by decreasing the levels of interleukin-1β (IL-1 β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF- α), interleukin-8 (IL-8) and myeloperoxidase (MPO) in the lung and bronchioalveolar lavage fluid. Consistent with the findings in vivo, EFL2 also showed robust inhibitory effects on the production of IL-1 β, IL-6, TNF- α and IL-8 released from LPS-stimulated RAW264.7 cells in vitro. Interestingly, this effect appeared to be mediated by EFL2's inhibition of NF-κB signaling activation, but not the MAPK pathway. Not only phosphorylation of IKK α/β and IκBα was down-regulated, p65 translocation and its DNA-binding activity were also significantly suppressed by EFL2. Moreover, overexpression of p65 reversed the inhibitory effect of EFL2 in LPS-induced NF-κB activation and cytokines production. The observed anti-inflammatory bioactivity of EFL2 indicates its potential as a drug development candidate, particularly for LPS-mediated disorders of inflammation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Euphorbia Factor L 2, Euphorbia Factor L2, Euphorbia Factor L-2, euphorbiafactor L2, Inhibitor, inhibit, NFκB, NF-κB, NFkB, NF-kB

Compound Identifiers

PubChem CID

10627939