Euphorbia factor L1

SKU: orb1304702

Description

Euphorbia factor L1

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 76376-43-7
• MW: 552.66
• Purity: 98.16%
• Formula: C₃₂H₄₀O₈
• SMILES: O(C(C)=O)[C@]12[C@@]([C@@H](OC(C)=O)[C@@]3(CO3)CC[C@]4([C@@](\C=C(\C)/C1=O)(C4(C)C)[H])[H])([C@@H](OC(CC5=CC=CC=C5)=O)[C@@H](C)C2)[H]
• Target: Apoptosis,P-gp
• Solubility: Methanol:Soluble;DMSO:37 mg/mL (66.95 mM);Ethanol:Soluble

Bioactivity

• In Vitro:
  Euphorbiasteroid suppresses adipogenic differentiation of 3T3‐L1 cells, mainly at the early stage, and stimulates the AMPK signalling pathway. The anti-adipogenic effects of euphorbiasteroid could possibly be attributed to activation of the AMPK pathway, by decreasing the level of FAS and its up-regulators, including C/EBPs, PPAR-γ and SREBP-1c, without involving insulin signalling pathway. Euphorbiasteroid could be a transport substrate for P-gp that can effectively inhibit P-gp-mediated drug transport and reverse resistance to anticancer drugs in MES-SA/Dx5 cells.
• Cell Research:
  3T3‐L1 cells were treated with euphorbiasteroid at concentrations of 6.25, 12.5, 25 and 50 μM for 2 days in adipogenesis induction medium, 2 days in adipogenesis medium and 2 days in culture medium (CM) sequentially during differentiation. Intracellular triglycerides (TGs) were stained with Oil red O (ORO) solution.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ABCB1, Apoptosis, Euphorbiasteroid, Euphorbia factor L1, Euphorbia factor L-1, Pgp

Compound Identifiers

PubChem CID

101071470