Eupatolide

SKU: orb1682589

Description

Eupatolide, a sesquiterpene lactone isolated from Inula japonica flowers, exhibits anti-inflammatory activity. It is a useful research tool for investigating mechanisms of TRAIL resistance in breast cancer cells, with applications in both in vitro and in vivo oncology studies.

Research Area

Cardiovascular Research, Cell Biology, Immunology & Inflammation, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 6750-25-0
• MW: 248.32
• Formula: C₁₅H₂₀O₃
• SMILES: C=C1[C@]2([C@](OC1=O)(/C=C(\C)/CC/C=C(\C)/C[C@H]2O)[H])[H]
• Target: PDGFR,Akt,MAPK,TNF,ROS,NO Synthase,NF-κB,NOS,COX,Autophagy,Nrf2,DNA/RNA Synthesis,Prostaglandin Receptor

Bioactivity

• In Vitro:
  Eupatolide exhibits potent cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cancer cell lines (IC50: 1.57 to 22.58 uM). Eupatolide sensitizes breast cancer cells to TRAIL through the down-regulation of c-FLIP expression. In RAW264.7 cells, Eupatolide inhibits lipopolysaccharide-induced COX-2 and iNOS expression by inducing proteasomal degradation of TRAF6. Eupatolide suppresses PDGF-induced proliferation and migration of VSMC through HO-1 induction via ROS-Nrf2 pathway and may be a potential HO-1 inducer for preventing or treating vascular diseases.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AP-1, Akt, COX, DNA Synthesis, DNASynthesis, HO-1, MAPK, Eupatolide, NOS, NOSynthase, Nrf2, NO Synthase, NO, PDGFR, NFκB, NF-κB, NFkB, NF-kB, p65, PGE, Prostaglandin Receptor, ProstaglandinReceptor, TNF-α, RNA Synthesis, RNASynthesis, ROS

Compound Identifiers

PubChem CID

5281460