Eudesmin

SKU: orb1220285

Description

Eudesmin shows antiinflammatory neuritogenic anticonvulsant and sedative effects the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions and anti-apoptosis of neuron the in brain.50 microM (+)-eudesmin can induce neurite outgrowth and enhance nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells by stimulating up-stream MAPK PKC and PKA pathways.

Key Properties

• CAS Number: 526-06-7
• MW: 386.4
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₆O₆
• SMILES: COc(ccc([C@@H]1OC[C@H]2[C@H](c(cc3)cc(OC)c3OC)OC[C@@H]12)c1)c1OC
• Target: p38 MAPK
• Solubility: In Vitro: DMSO : 100 mg/mL (258.77 mM)

Bioactivity

• In Vitro:
  Treatment of mesenchymal stem cells (MSCs) with Eudesmin (20, 40, and 80 μM) disturbs adipogenesis via suppression of S6K1 signaling pathway. Eudesmin treatment inhibits activation and nuclear translocation of S6K1. S6K1-mediated phosphorylation of H2B at serine 36 (H2BS36p) is reduced upon Eudesmin treatment.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

p38 MAPK