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Eudesmin

SKU: orb1220285

Description

Eudesmin shows antiinflammatory neuritogenic anticonvulsant and sedative effects the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions and anti-apoptosis of neuron the in brain.50 microM (+)-eudesmin can induce neurite outgrowth and enhance nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells by stimulating up-stream MAPK PKC and PKA pathways.

Images & Validation

Key Properties

CAS Number526-06-7
MW386.4
Purity>98% (HPLC)
FormulaC22H26O6
SMILESCOc(ccc([C@@H]1OC[C@H]2[C@H](c(cc3)cc(OC)c3OC)OC[C@@H]12)c1)c1OC
Targetp38 MAPK
SolubilityIn Vitro: DMSO : 100 mg/mL (258.77 mM)

Bioactivity

In Vitro
Treatment of mesenchymal stem cells (MSCs) with Eudesmin (20, 40, and 80 μM) disturbs adipogenesis via suppression of S6K1 signaling pathway. Eudesmin treatment inhibits activation and nuclear translocation of S6K1. S6K1-mediated phosphorylation of H2B at serine 36 (H2BS36p) is reduced upon Eudesmin treatment.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

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200 mg
500 mg
5 mg
$ 720.00
10 mg
$ 1,050.00
25 mg
$ 1,640.00
50 mg
$ 2,200.00
100 mg
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