Etofibrate

SKU: orb1305322

Description

Etofibrate

Key Properties

• CAS Number: 31637-97-5
• MW: 363.79
• Purity: 99.42%
• Formula: C₁₈H₁₈ClNO₅
• SMILES: CC(C)(Oc1ccc(Cl)cc1)C(=O)OCCOC(=O)c1cccnc1
• Target: Others
• Solubility: Ethanol:68 mg/mL (186.92 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:68 mg/mL (186.92 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.5 mM)

Bioactivity

• In Vivo:
  Etofibrate significantly reduce the concentration of cholesterol, triglycerides, free fatty acids, and glycerol, In both total and unesterified forms, in the microsomal fraction of rat liver plasma. It increase the activity of glycerol-3-phosphate dehydrogenase in hepatocytes, which leads to a reduction in the activities of microsomal HMG-CoA reductase and cholesterol 7α-hydroxylase without affecting acyl CoA: cholesterol acyltransferase. Moreover, etofibrate boost the activity of cytosolic glyceraldehyde-3-phosphate dehydrogenase an the ove All concentration of carnitine in rat liver, consequently lowerin the concentration of triglycerides and cholesterol. When fed rats' epididymal adipose tissue is cultured under basal conditions, etofibrate stimulate the rate of fatty acid re-esterification. It reduce the action of lipolytic products in the liver by releasing lipolytic products from adipose tissue and through intrinsic liver metabolism.
• In Vitro:
  Administering 200 mg/kg of Etofibrate results in significant Inhibition of neointimal proliferation of smooth musclee cells in a rabbit model of atherosclerosis, leading to less pronounced plaque expansion. Additionally, 1.2 mM g of Etofibrate lowers plasma free fatty acid (FFA) levels in Male Sprague Dawley rats the effect of Etofibrate on plasma glycerol levels varies depending o the dosage and duration of treatment, either increasing or decreasing these levels.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Etofibrate

Compound Identifiers

PubChem CID

65777