ETI60

SKU: orb3173699

Description

ETI60 is an orally active selective TLR inhibitor that targets the nucleoside-binding sites I of TLR7 (IC50 = 0.68 μM) and TLR9 (IC50 = 0.12 μM) without affecting surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4, and TLR5). It demonstrates nanomolar activity in cell-based, biophysical, and in vivo assays, effectively inhibiting endosomal TLR-mediated pro-inflammatory signaling. ETI60 modulates the expression of genes related to inflammation and significantly improves symptoms in mouse models of psoriasis and systemic lupus erythematosus (SLE). ETI60 is applicable in studies related to autoimmune and inflammatory diseases.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2773475-11-7
• MW: 352.48
• Formula: C₂₁H₂₈N₄O
• SMILES: N1=C2C(=C(N)C3=C1CCCC3)C=4C=CC(OC)=CC4N2CCCN(C)C
• Target: JNK,Interleukin,TNF,ERK,p38 MAPK,NF-κB,TLR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

JNK,Interleukin,TNF,ERK,p38 MAPK,NF-κB,TLR