ETI41

SKU: orb3173752

Description

ETI41 is an orally active selective TLR inhibitor that targets the nucleoside-binding site I of TLR7 (IC50= 0.63 μM) and TLR9 (IC50= 0.16 μM), without affecting surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4, and TLR5). It demonstrates nanomolar activity in cell-based, biophysical, and in vivo studies, effectively inhibiting endosomal TLR-mediated pro-inflammatory signaling. ETI41 suppresses the expression of inflammation-related genes and significantly improves symptoms in mouse models of psoriasis and systemic lupus erythematosus (SLE). ETI41 is applicable in research related to autoimmune and inflammatory diseases.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2773474-99-8
• MW: 314.48
• Formula: C₁₉H₃₀N₄
• SMILES: N=1C2=C(C=C(N2CCCN(C)C)C)C(N)=C3C1CCCCCC3
• Target: JNK,Interleukin,TNF,p38 MAPK,ERK,NF-κB,TLR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

JNK,Interleukin,TNF,p38 MAPK,ERK,NF-κB,TLR