ETHYL CAFFEATE

SKU: orb1301589

Description

Ethyl Caffeate is a small molecule that potently inhibits Th1 cell differentiation in vitro by suppressing key transcriptional elements of the IFN-γ signaling pathway, including T-bet, STAT1, and STAT4. This makes it a valuable research tool for studying T-cell immunology, autoimmune diseases, and inflammatory conditions in experimental models.

Research Area

Immunology & Inflammation, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 102-37-4
• MW: 208.21
• Purity: 98.00% (May vary between batches)
• Formula: C₁₁H₁₂O₄
• SMILES: O=C(OCC)C=CC1=CC=C(O)C(O)=C1
• Target: NF-κB,COX,NO Synthase,PGE Synthase
• Solubility: DMSO:41 mg/mL (196.92 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.61 mM)

Bioactivity

• In Vivo:
  Shikui X , Aixue Z , Zengjun G , et al. Ethyl Caffeate Ameliorates Collagen-Induced Arthritis by Suppressing Th1 Immune Response[J]. Journal of Immunology Research, 2017, 2017:1-11.
• In Vitro:
  In vivo, ETHYL CAFFEATE(ECF) treatment reduced the severity of collagen-induced arthritis (CIA), inhibited IFN-γ and IL-6 secretion, and decreased the proportion of CD11b+Gr-1+ splenic neutrophil. Meanwhile, ECF treatment significantly inhibited the IFN-γ expression in CD4+T cell without obviously influencing the development of Th17 cells and T regulatory cells.
• Cell Research:
  Collagen was dissolved in 0.1 M acetic acid at 4°C overnight. Male DBA/1 mice were immunized at the tail base with 125 μg of collagen emulsified in complete Freund's adjuvant (CFA) containing Mycobacterium tuberculosis strain H37Rv. Each mouse was then boosted with the same amount of collagen plus CFA 21 days later (taken as day 0). Starting from day 9 for 10 consecutive days, the mice were administered daily with ECF (50 mg/kg) or methotrexate (2 mg/kg)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PGE Synthase, PGE synthase, PGESynthase, Prostaglandin E synthase, Nuclear factor-kappaB, Nuclear factor-κB, Nitric oxide synthases, NO Synthase, NFκB, NFkB, NF-kB, NF-κB, inhibit, Inhibitor, NOSynthase, NOS, ETHYL 3,4-DIHYDROXYCINNAMATE, ETHYL CAFFEATE, COX, Cyclooxygenase

Compound Identifiers

PubChem CID

66883