Ethamsylate

SKU: orb1311038

Description

Ethamsylate (Dicynene) is a hemostatic agent that enhances capillary resistance and platelet adhesion while suppressing prostaglandin synthesis and activity. It is utilized in research models investigating hemostasis, bleeding disorders, and vascular integrity in both in vitro and in vivo experimental settings.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2624-44-4
• MW: 263.31
• Purity: 99.98% (May vary between batches)
• Formula: C₁₀H₁₇NO₅S
• SMILES: Oc1cc(c(O)cc1)S(=O)(=O)O.C(NCC)C
• Target: Prostaglandin Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (9.49 mM);DMSO:50 mg/mL (189.89 mM)

Bioactivity

• In Vivo:
  High concentrations of Ethamsylate were able to remove superoxide radicals. In the presence of Ethamsylate, arachidonic acid, thromboxane A2, collagen, and the calcium carrier A23187 promoted the induction of human platelet aggregation and the release of ATP.Ethamsylate inhibited the production of prostaglandins in the microsomes of pregnant women's uterine myometrium at an IC50 of 0.5 mM. Ethamsylate was highly effective in inhibiting hydroxyl radicals (OH.) at concentrations of 0.1-10 μM.
• In Vitro:
  High concentrations of Ethamsylate were able to remove superoxide radicals. In the presence of Ethamsylate, arachidonic acid, thromboxane A2, collagen, and the calcium carrier A23187 promoted the induction of human platelet aggregation and the release of ATP.Ethamsylate inhibited the production of prostaglandins in the microsomes of pregnant women's uterine myometrium at an IC50 of 0.5 mM. Ethamsylate was highly effective in inhibiting hydroxyl radicals (OH.) at concentrations of 0.1-10 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclonamine, Dicynene, Aglumin, inhibit, Etamsylate, Ethamsylate, Inhibitor, ProstaglandinReceptor, Prostaglandin Receptor

Compound Identifiers

PubChem CID

17506