ETC-159

SKU: orb1303253

Description

ETC-159 is a potent and orally bioavailable small molecule inhibitor of PORCN, demonstrating an IC50 of 2.9 nM in β-catenin pathway reporter assays. It is a valuable research tool for investigating Wnt/β-catenin signaling in various cancer models, both in vitro and in vivo.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1638250-96-0
• MW: 391.38
• Purity: 96.87% (May vary between batches)
• Formula: C₁₉H₁₇N₇O₃
• SMILES: Cn1c2ncn(CC(=O)Nc3ccc(nn3)-c3ccccc3)c2c(=O)n(C)c1=O
• Target: Porcupine,Wnt/beta-catenin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.11 mM);DMSO:55 mg/mL (140.53 mM)

Bioactivity

• Target IC50:
  β-catenin:2.9 nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

beta-catenin, betacatenin, bcatenin, Inhibitor, ETC 159, ETC 1922159, ETC159, ETC-159, ETC1922159, ETC-1922159, inhibit, Porcupine, Porcn, Wnt, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, βcatenin, β-catenin

Compound Identifiers

PubChem CID

86280523