Estrone O-sulfamate

SKU: orb1744882

Description

Estrone 3-O-sulfamate is a potent and selective steroid sulfatase (STS) inhibitor, demonstrating nanomolar IC50 values in both placental microsomes and MCF-7 cell assays. This compound is a valuable research tool for investigating STS-dependent pathways in cancer research, including in vitro and in vivo models of hormone-dependent malignancies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 148672-09-7
• MW: 349.44
• Purity: 99.89% (May vary between batches)
• Formula: C₁₈H₂₃NO₄S
• SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(OS(N)(=O)=O)=CC4)(CC1)[H])[H])(CCC2=O)[H]
• Target: Others
• Solubility: DMSO:55 mg/mL (157.39 mM)

Bioactivity

• Target IC50:
  STS (P.M.):18 nM|STS (MCF-7 cells):0.83 nM
• In Vitro:
  In both placental microsome (P.M.) preparations and MCF-7 cells, Estrone O-sulfamate (Estrone 3-O-sulfamate) exhibits inhibitory activity against STS, with IC50 values of 18 nM and 0.83 nM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Estrone 3-O-sulfamate, Estrone O-sulfamate, STS

Compound Identifiers

PubChem CID

127676