Esomeprazole

SKU: orb1940496

Description

Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI).(In Vivo):In an orthotopic transplantation nude mouse model, Esomeprazole reduced lung metastasis of MDA-MB-231 breast cancer cells.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 119141-88-7
• MW: 345.42
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₉N₃O₃S
• SMILES: O=[S@](C1=NC2=CC(OC)=CC=C2N1)CC3=NC=C(C)C(OC)=C3C
• Target: Proton Pump
• Solubility: In Vitro: DMSO : 125 mg/mL (361.88 mM)

Bioactivity

• In Vivo:
  Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis. Animal model: C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury. Dosage: 30 mg/kg, 300 mg/kg. Administration: Oral gavage; daily; for 19 or 11 days. Result: Significantly inhibited the progression of fibrosis throughout the lungs of the animals.
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• In Vitro:
  Esomeprazole (25-100 μM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification. Cell Viability Assay Cell line: MDA-MB-468 cells. Concentration: 25 μM, 50 μM, 75 μM, 100 μM. Incubation time: 20 hours. Result: Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Proton Pump