Esomeprazole

SKU: orb1306590

Description

Esomeprazole, the S-isomer of omeprazole, is a proton pump inhibitor that also acts as a selective inhibitor of the lysosomal cysteine protease legumain. This dual activity makes it a research tool for investigating mechanisms of cancer metastasis in both cellular and animal models.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 119141-88-7
• MW: 345.42
• Purity: 98.20% (May vary between batches)
• Formula: C₁₇H₁₉N₃O₃S
• SMILES: COC1=CC2=C(C=C1)N=C(N2)[S@@](=O)CC1=NC=C(C)C(OC)=C1C
• Target: Proton pump|||Cysteine Protease
• Solubility: DMSO:1 mg/mL (2.9 mM)

Bioactivity

• In Vivo:
  In an orthotopic transplantation nude mouse model, Esomeprazole reduced lung metastasis of MDA-MB-231 breast cancer cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

lysosomal cysteine protease, K+-ATPase, inhibit, Esomeprazole, fibrosis, Inhibitor, gastroesophageal, CYP3A4, Cysteine Protease, CysteineProtease, (S)-Omeprazole, antacid, anti-inflammation, Proton pump, Proton Pump, Protonpump

Compound Identifiers

PubChem CID

9568614