ESI1

SKU: orb2665409

Description

ESI1 is a small molecule epigenetic inhibitor that triggers SREBP1/2 nuclear aggregation to co-opt transcriptional co-activators, upregulating lipid and cholesterol biosynthesis. It has demonstrated pro-myelination activity in vivo, promoting remyelination in animal models of demyelination and supporting axon regeneration, which correlates with improved cognitive function in aged models.

Research Area

Metabolism Research

Key Properties

• MW: 355.82
• Formula: C₁₈H₁₈ClN₅O
• SMILES: O=C(NC1=C(N)C=CC=C1)C(C=N2)=NC=C2NCC3=CC=CC=C3.Cl
• Target: Endogenous Metabolite

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

175663108