ESI-08

SKU: orb1309689

Description

ESI-08 is a selective EPAC2 antagonist with an IC50 of 8.4 µM, effectively inhibiting cAMP-induced EPAC activation without affecting PKA. This tool compound is widely used in vitro and in vivo to study EPAC2's role in insulin secretion, neuronal signaling, and cardiovascular function.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 301177-43-5
• MW: 353.48
• Purity: 99.05% (May vary between batches)
• Formula: C₂₀H₂₃N₃OS
• SMILES: Cc1ccc(C)c(CSc2nc(C3CCCCC3)c(C#N)c(=O)[nH]2)c1
• Target: Ras,cAMP
• Solubility: DMSO:50 mg/mL (141.45 mM)

Bioactivity

• Target IC50:
  EPAC2:8.4 μM
• In Vitro:
  ESI-08 (25 μM) does not alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cAMP, inhibit, Inhibitor, EPAC1, EPAC, EPAC2, exchange, ESI 08, ESI08, ESI-08, Ras, proteins

Compound Identifiers

PubChem CID

135473051