ESI-05

SKU: orb1308326

Description

ESI-05 (NSC-116966) is a selective EPAC2 antagonist with an IC50 of 0.4 µM, effectively blocking cAMP-induced EPAC2 activation and subsequent Rap1 signaling. This tool compound is utilized in vitro and in vivo to investigate EPAC2's role in insulin secretion, neuronal function, and potential therapeutic applications for diabetes and neurological disorders.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 5184-64-5
• MW: 274.38
• Purity: 98.00% (May vary between batches)
• Formula: C₁₆H₁₈O₂S
• SMILES: Cc1ccc(cc1)S(=O)(=O)c1c(C)cc(C)cc1C
• Target: Acyltransferase,cAMP
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (12.03 mM);DMSO:83.33 mg/mL (303.7 mM)

Bioactivity

• Target IC50:
  EPAC2:0.4 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Diglyceride acyltransferase, Diacylglycerol acyltransferase, diabetes, acyl-CoA:cholesterol acyltransferase, Acyltransferase, cAMP, inhibit, Intracranial hemorrhage (ICH), NSC 116966, NSC116966, NSC-116966, Inhibitor, neurological disorders, insulin secretion, GEF, mono- acylglycerol acyltransferase, ESI 05, ESI05, ESI-05, EPAC2, exchange proteins directly activated by cAMP 2 (EPAC2)

Compound Identifiers

PubChem CID

272513