ES9-17

SKU: orb1819237

Description

ES9-17 is a chemical analog of Endosidin9 that potently inhibits clathrin-mediated endocytosis (CME), as demonstrated by its suppression of FM4-64 and transferrin uptake. This inhibitor is a valuable research tool for studying CME in both plant and animal systems, with in vivo applications including the inhibition of Arabidopsis thaliana root growth.

Research Area

Signal Transduction

Key Properties

• CAS Number: 55854-43-8
• MW: 318.21
• Purity: >99.99% (May vary between batches)
• Formula: C₁₀H₈BrNO₂S₂
• SMILES: BrC1=CC=C(S1)S(=O)(=O)NC1=CC=CC=C1
• Target: Dynamin,Others
• Solubility: DMSO:125 mg/mL (392.82 mM)

Bioactivity

• In Vitro:
  ES9-17 (0-100 μM; 30 min) inhibits the absorption of the lipophilic styrene-based endocytosis tracer (FM4-64) with an EC50 of 13 μM, does not deplete ATP in Arabidopsis cells at 30 μM for 30 min, reduces the uptake of transferrin in HeLa cells at 30 μM for 30 min , targets CHC, regulates the inner membrane transport pathway, and does not cause cytoplasmic acidification .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ES917, ES9-17, clathrin-mediated endocytosis

Compound Identifiers

PubChem CID

893416