ES-072

SKU: orb2665524

Description

ES-072 is an orally active, selective EGFR-T790M inhibitor that induces PD-L1 degradation via GSK3α-mediated phosphorylation and ARIH1-dependent ubiquitination. This dual action suppresses NSCLC cell proliferation in vitro and enhances anti-tumor immunity, supporting its research in targeted therapy and immuno-oncology.

Research Area

Cardiovascular Research, Cell Biology, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2089721-94-6
• MW: 528.53
• Formula: C₂₅H₂₇F₃N₈O₂
• SMILES: O=C(C=C)NC1=CC=CC(=C1)NC2=NC(=NC=C2C(F)(F)F)NC=3C=CC(=NC3OC)N4CCN(C)CC4
• Target: GSK-3,EGFR,PD-1/PD-L1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

135267949