Erythromycin estolate

SKU: orb1707328

Description

Erythromycin estolate is an orally bioavailable macrolide antibiotic that inhibits bacterial protein synthesis, used in research for susceptible respiratory and skin infections. Studies employ it in both in vitro susceptibility assays and in vivo infection models, noting its potential hepatotoxicity including cholestatic injury.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3521-62-8
• MW: 1056.39
• Purity: 99.59% (May vary between batches)
• Formula: C₅₂H₉₇NO₁₈S
• SMILES: CCCCCCCCCCCCOS(O)(=O)=O.CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(C2OC(=O)CC)N(C)C)C(C)(O)CC(C)C(=O)C(C)C(O)C1(C)O
• Target: Antibiotic,Anti-infection,Antibacterial
• Solubility: DMSO:45 mg/mL (42.6 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.89 mM)

Bioactivity

• In Vitro:
  Erythromycin estolate effectively inhibited HCoV-OC43 infection in different cell types and significantly reduced virus titers at safe concentration without cell cytotoxicity. Furthermore, erythromycin estolate was identified to inhibit HCoV-OC43 infection at the early stage and to irreversibly inactivate virus by disrupting the integrity of the viral membrane whose lipid component might be the target of action. Together, it was demonstrated that erythromycin estolate could be a potential therapeutic drug for HCoV-OC43 infection.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ilosone, Erythromycin estolate, Bacterial, Phtalic anhydride

Compound Identifiers

PubChem CID

429694