Erucin

SKU: orb1700636

Description

Erucin is a dietary isothiocyanate derived from glucoerucin hydrolysis, studied for its chemopreventive potential. Research in vitro and in vivo investigates its roles in inducing apoptosis, modulating cell cycle proteins like p53 and p21, and influencing phase II detoxifying enzymes such as quinone reductase and glutathione S-transferase.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 4430-36-8
• MW: 161.29
• Purity: 99.97%
• Formula: C₆H₁₁NS₂
• SMILES: S=C=NCCCCSC
• Target: Cytochromes P450,NADPH,GST,p53,Apoptosis
• Solubility: DMSO:80 mg/mL (496 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (20.46 mM)

Bioactivity

• In Vivo:
  In a TPA-induced mouse ear edema model, Erucin (100 and 300 nMol) significantly reduced swelling and decreased iNOS and COX-2 expressio.
• In Vitro:
  In LPS-stimulated RAW 264.7 macrophages, Erucin (2.5 and 5 μMol/L) inhibited NO and PGE₂ production, suppressed NF-κB activity, and reduced expression of TNF-α, IL-6, IL-1β, iNOS, and COX-. In SH-SY5Y neuroblastoma cells, Erucin (5 μM) activate the Nrf2 pathway, increased intracellular GSH levels, and protected against 6-OHDA-induced oxidative stres. Erucin (30–100 μM) inhibits proliferation and migration, induces apoptosis, releases H₂S, and reduces ERK1/2 phosphorylation in AsPC-1 pancreatic cancer cell.

Storage & Handling

• Storage: store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

4-(Methylthio)butyl isothiocyanate, 1-isothiocyanato-4-methylsulfanylbutane

Compound Identifiers

PubChem CID

78160