Ermanin

SKU: orb1684618

Description

Ermanin, a flavonoid from Tanacetum microphyllum, exhibits anti-inflammatory activity by suppressing iNOS and COX-2 expression. It demonstrates research potential in studies of platelet aggregation, antimicrobial effects, and anti-HIV-1 activity, supported by in vitro and in vivo investigations including anti-tuberculosis and larvicidal assays.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Neuroscience, Protein Biochemistry

Key Properties

• CAS Number: 20869-95-8
• MW: 314.29
• Purity: 99.56% (May vary between batches)
• Formula: C₁₇H₁₄O₆
• SMILES: O(C)C1=C(OC=2C(C1=O)=C(O)C=C(O)C2)C3=CC=C(OC)C=C3
• Target: Influenza Virus,NO Synthase,HIV Protease,COX,NOS,Antibiotic,Antibacterial
• Solubility: DMSO:100 mg/mL (318.18 mM)

Bioactivity

• In Vitro:
  Ermanin (3.25, 6.25, 12.5, and 25 μM) on modulation of LPS-induced iNOS and COX-2 expression in RAW 264.7 cells. Ermanin decreased LPS-induced COX-2 and iNOS expression by 94 ± 0.5% and 94 ± 0.5% with IC50 were 1.68 μM and 6.70 μM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NOS, InfluenzaVirus, Influenza Virus, Influenza virus, NO Synthase, iNOS, HIVProtease, HIV-1, HIV Protease, Ermanin, COX-2, Bacterial, tuberculosis, PGE

Compound Identifiers

PubChem CID

5352001