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ERK5-IN-7

SKU: orb3210271

Description

ERK5-IN-7 is an orally active ERK5 inhibitor with an IC50 of 403.4 nM. It directly suppresses ERK5 kinase activity, reduces phosphorylation levels, and decreases total protein expression of ERK5. Additionally, ERK5-IN-7 induces apoptosis [Apoptosis] by upregulating Bax, downregulating Bcl-2, and promoting Caspase-3 cleavage. It also leads to the accumulation of reactive oxygen species (ROS) and exhibits anticancer effects against Lewis lung carcinoma.

Images & Validation

Key Properties

TargetCaspase,Bcl-2 Family,ROS,ERK,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information