Eribulin

SKU: orb1707961

Description

Eribulin (B1939) is a synthetic microtubule dynamics inhibitor that suppresses microtubule polymerization, halting the growth and shrinkage phases essential for cell division. It is widely used in preclinical research for metastatic breast cancer and various solid tumors, with applications in both in vitro cytotoxicity assays and in vivo xenograft models.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 253128-41-5
• MW: 729.90
• Purity: 99.96% (May vary between batches)
• Formula: C₄₀H₅₉NO₁₁
• SMILES: [H][C@@]12CC(=C)[C@]([H])(CC[C@@]3([H])C[C@@H](C)C(=C)[C@@]([H])(C[C@]4([H])O[C@H](C[C@H](O)CN)[C@H](OC)[C@@]4([H])CC(=O)C[C@@]4([H])CC[C@]5([H])O[C@@]6([H])[C@@]7([H])O[C@@]8(C[C@@]7([H])O[C@@]6([H])[C@@]([H])(O8)[C@@]5([H])O4)CC1)O3)O2
• Target: Apoptosis,ADC Cytotoxin,Microtubule Associated
• Solubility: DMSO:100 mg/mL (137.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (6.85 mM)

Bioactivity

• In Vivo:
  In 4-week-old C3H/HeN mice injected with LM8 cells, Eribulin (1 mg/kg; intravenous injection, once a week for 2 weeks) suppressed primary tumor growth and induced apoptosis in tumor cells. It also reduced the occurrence of lung metastasis and led to a decrease in body weight.
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• In Vitro:
  In LM8 and Dunn cells, Eribulin inhibited cell proliferation in a dose-dependent manner at concentrations of 0, 1, 10, and 100 nM for 72 hours.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ER086526, ER-086526, Eribulin, ER 086526, MicrotubuleAssociated, Microtubule Associated, microtubule, B 1939, B-1939, B1939, ADCCytotoxin, ADC Cytotoxin, E7389, E-7389, E 7389

Compound Identifiers

PubChem CID

11354606