Ercalcidiol

SKU: orb1940726

Description

Ercalcidiol is a metabolite of vitamin D2 and can be used in monitoring vitamin D therapy.(In Vitro):The half-life of Ercalcidiol is shorter than that of 25(OH)D3 and Ercalcidiol binds less well to the vitamin D binding protein, making Ercalcidiol less potent and required much higher doses than vitamin D3 .

Key Properties

• CAS Number: 21343-40-8
• MW: 412.658
• Purity: >98% (HPLC)
• Formula: C₂₈H₄₄O₂
• SMILES: [H][C@@]12CC[C@H]([C@H](C)\C=C\[C@H](C)C(C)(C)O)[C@@]1(C)CCC\C2=C/C=C1/C[C@@H](O)CCC1=C
• Target: Endogenous Metabolite
• Solubility: In Vitro: DMSO : 200 mg/mL (484.67 mM)

Bioactivity

• In Vitro:
  Differentiation between Ercalcidiol (25(OH)D2) and 25(OH)D3 is important for monitoring vitamin D therapy, as vitamin D2 is the predominant prescription form. The half-life of Ercalcidiol is shorter than that of 25(OH)D3 and it binds less well to the vitamin D binding protein, making it less potent and, therefore, required to be administered at much higher doses than vitamin D3. Some currently used assays have a diminished capacity to detect Ercalcidiol, which can lead to dangerous overdosing when attempting to monitor therapy with vitamin D2.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

25-hydroxy Vitamin D2

Quick Database Links

Gene Symbol

Endogenous Metabolite