Eras-4001

SKU: orb3218127

Description

Eras-4001 is a small-molecule pan-KRAS inhibitor capable of targeting both wild-type KRAS and various mutant forms simultaneously. Eras-4001 inhibits signaling between KRAS and effector proteins such as RAF, thereby blocking the activity of the RAS/MAPK pathway. In preliminary studies, this compound has demonstrated high affinity for KRAS (nano-molar IC50) and induced tumor regression in multiple KRAS-mutant tumor models, indicating potential value for antitumor therapy.

Key Properties

• CAS Number: 3024878-19-8
• MW: 743.19
• Purity: 99.79% (May vary between batches)
• Formula: C₃₆H₃₉ClF₄N₈O₃
• SMILES: C(OC1=NC(=C2C(=N1)C[C@H](OC2)C3=C(C(F)(F)F)C(C#CC)=CC(N)=C3F)N4CC=5N(CCC4)N=C(C(N(C)C)=O)C5Cl)[C@@]67N(CC(=C)C6)CCC7
• Target: Ras,Kras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras,Kras