ER-464195-01

SKU: orb3173174

Description

ER-464195-01 is an orally active inhibitor that targets the interaction between CRT and ITGAs. By disrupting the binding of CRT and ITGAs, ER-464195-01 reduces leukocyte infiltration and subsequent inflammatory cascade reactions. It downregulates the expression of pro-inflammatory genes induced by DSS, such as [TNF-α], [IL-1β], [IL-6], [IL-17f], and inhibits the phosphorylation of STAT3 and the production of serum amyloid A (SAA). This compound is applicable for research in inflammatory bowel disease (IBD).

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 859218-37-4
• MW: 379.03
• Formula: C₂₃H₃₉ClN₂
• SMILES: Cl.C=1C=CC(=C(C1)N2CCN(CC2)CCC)C3CC(C)(C)CC(C)(C)C3
• Target: STAT,Interleukin,TNF

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

STAT,Interleukin,TNF