EPZ011989

SKU: orb1305491

Description

EPZ011989 is a potent, selective, and orally bioavailable inhibitor of EZH2, with sub-nanomolar affinity for both wild-type and Y646 mutant forms. It demonstrates high selectivity over EZH1 and other histone methyltransferases. This compound is a valuable chemical probe for studying PRC2 function in cancer models, including lymphoma, both in vitro and in vivo.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1598383-40-4
• MW: 605.81
• Purity: 99.81% (May vary between batches)
• Formula: C₃₅H₅₁N₅O₄
• SMILES: CCN([C@H]1CC[C@@H](CC1)N(C)CCOC)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C#CCN1CCOCC1
• Target: Histone Methyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.65 mM);Ethanol:100 mg/mL (165.07 mM);DMSO:3.8 mg/mL (6.27 mM)

Bioactivity

• Target IC50:
  EZH2:<3 nM(Ki)|EZH1:103 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, EZH2, EPZ 011989, EPZ011989, EPZ-011989, Histone Methyltransferase, HistoneMethyltransferase, Inhibitor

Compound Identifiers

PubChem CID

73670548