EPZ-4777

SKU: orb2664465

Description

EPZ-4777 is a potent and selective DOT1L inhibitor that suppresses leukemogenic gene expression by blocking H3K79 methylation. It is widely used in cancer research to study mixed lineage leukemia (MLL) both in vitro and in vivo, demonstrating selective activity against cells with MLL gene translocations.

Key Properties

• CAS Number: 1381761-52-9
• MW: 540.66
• Formula: C₂₇H₄₀N₈O₄
• SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CN(CCCNC(NC4=CC=C(C(C)(C)C)C=C4)=O)C(C)C)[C@H]1O

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

56951879