(-)-Epigallocatechin-3-(3''-O-methyl) gallate

SKU: orb1684629

Description

(-)-EGCG-3''-O-ME is a methylated catechin from tea, exhibiting potent antioxidant, cytotoxic, and antibacterial properties. Its application in dental research includes enhancing dentin adhesive stability. Studies investigate its bioactivity in vitro for potential chemopreventive and antimicrobial roles.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 83104-87-4
• MW: 472.4
• Purity: 99.63% (May vary between batches)
• Formula: C₂₃H₂₀O₁₁
• SMILES: O(C(=O)C1=CC(OC)=C(O)C(O)=C1)[C@H]2[C@H](OC=3C(C2)=C(O)C=C(O)C3)C4=CC(O)=C(O)C(O)=C4
• Target: Antioxidant,Antibacterial

Bioactivity

• Target IC50:
  α-amylase:0.54 mg/mL|COX-2:0.17 ± 0.03 μM|DPPH-derived radicals:36.54 μM|ABTS radicals:2.59 μM
• In Vitro:
  (-)-Epigallocatechin-3-(3''-O-methyl) gallate (3″Me-EGCG) (0–12.5 μM; 30 min; 37 °C) demonstrated scavenging effects in both HaCaT cell and cell-free systems. 3″Me-EGCG (6.25、12.5 μM) increased cell viability and heme oxygenase 1 (HO-1) expression under H2O2 exposure and protected keratinocytes while regulating the survival protein AKT1 under ultraviolet B (UVB) and sodium nitroprusside (SNP) exposure.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, Antioxidant, (-)-EGCG-3''-O-ME, Immunology & Inflammation related, Epigallocatechin-3-(3''-O-methyl) gallate, EGCG-3''-O-ME

Compound Identifiers

PubChem CID

9804842