EphB4-IN-1

SKU: orb3210247

Description

EphB4-IN-1 is a selective tyrosine kinase inhibitor of EphB4, exhibiting an IC50 value range of 0.16-0.30 μM. It binds to the ATP-binding site of EphB4 in the DFG-in conformation, creating four stable intermolecular hydrogen bonds. Additionally, EphB4-IN-1 inhibits kinases such as Src, Abl1, Lck, and EGFR and prevents the autophosphorylation of EphB4. This compound is applicable in cancer research, including studies on non-small cell lung cancer.

Key Properties

• CAS Number: 1394837-94-5
• MW: 322.36
• Formula: C₁₈H₁₈N₄O₂
• SMILES: O=C1C2=C(C=3C(=NC=NC3N1C4=CC(O)=CC=C4C)N)CCCC2
• Target: Src,Bcr-Abl,EGFR,Ephrin Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Src,Bcr-Abl,EGFR,Ephrin Receptor