Epertinib hydrochloride

SKU: orb1309696

Description

Epertinib hydrochloride is a potent, orally bioavailable, and selective reversible inhibitor of EGFR, HER2, and HER4 tyrosine kinases. It demonstrates significant antitumor activity in preclinical research, including in vitro cell-based assays and in vivo xenograft models, particularly for cancers driven by these receptors.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2071195-74-7
• MW: 596.48
• Purity: 99.14%
• Formula: C₃₀H₂₈Cl₂FN₅O₃
• SMILES: Cl.CC#C\C(=N/OC[C@H]1COCCN1)c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1
• Target: EGFR,HER
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.71 mM);DMSO:125 mg/mL (209.56 mM)

Bioactivity

• Target IC50:
  HER4:2.49 nM|HER2:7.15 nM|EGFR:1.48 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Epidermal growth factor receptor, Epertinib, Epertinib Hydrochloride, Epertinib hydrochloride, EGFR, ErbB-1, Inhibitor, HER4, HER2, HER1, S 22611, S 22611 Hydrochloride, S-22611, S22611 Hydrochloride, S-22611 hydrochloride, S-22611 Hydrochloride, S22611

Compound Identifiers

PubChem CID

139290994