Entacapone

SKU: orb1306079

Description

Entacapone

Research Area

Metabolism Research

Key Properties

• CAS Number: 130929-57-6
• MW: 305.29
• Purity: 98.88%
• Formula: C₁₄H₁₅N₃O₅
• SMILES: CCN(CC)C(=O)C(=C/c1cc(O)c(O)c(c1)[N+]([O-])=O)\C#N
• Target: Transferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.55 mM);Ethanol:2 mg/mL (6.55 mM);DMSO:250 mg/mL (818.89 mM)

Bioactivity

• Target IC50:
  COMT:151 nM
• In Vivo:
  In various tissues, such as the liver, duodenum, kidney, and lung, Entacapone inhibits the activity of catechol-O-methyltransferase (COMT). Additionally, in PC12 cells, Entacapone can suppress extracellular cytotoxicity induced by the aggregation of α-syn and β-amyloid (Aβ).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

COMT, ?FTO?knockdown, 116314-67-1, inhibit, OR611, OR-611, OR 611, Parkinson's disease, metabolic disorder, Inhibitor, Entacapone

Compound Identifiers

PubChem CID

21864625