Enpp/Carbonic anhydrase-IN-2

SKU: orb1819026

Description

Enpp/Carbonic Anhydrase-IN-2 is a potent dual inhibitor targeting ectonucleotide pyrophosphatase/phosphodiesterase (NPP1-3) and tumor-associated carbonic anhydrases (CA-IX/XII), with IC50 values in the sub-micromolar range. It exhibits selective antiproliferative and pro-apoptotic activity against cancer cells in vitro, making it a valuable tool for oncology research, particularly in studying hypoxia and acidosis in the tumor microenvironment.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 2883495-39-2
• MW: 429.5
• Purity: 99.46% (May vary between batches)
• Formula: C₂₃H₂₄FNO₄S
• SMILES: C(NC1=CC=C(OS(=O)(=O)C2=CC=C(F)C=C2)C=C1)(=O)C34CC5CC(C3)CC(C4)C5
• Target: PDE,Apoptosis,Carbonic Anhydrase
• Solubility: DMSO:40 mg/mL (93.13 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.66 mM)

Bioactivity

• Target IC50:
  NPP2:1.07 μM|CA IX:0.33 μM|NPP3:0.74 μM|CA XII:0.68 μM|NPP1:1.13 μM
• In Vitro:
  Enpp/Carbonic anhydrase-IN-2 (compound 1i) (0-2 µM) exhibits low cytotoxicity against normal breast epithelial cells (HME1) and normal skin fibroblast cells (F180) with IC50s > 50 µM. Enpp/Carbonic anhydrase-IN-2 (0-100 µM) inhibits the growth of various cancer cells, showing IC50s of 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, and 0.83 µM for K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, and T-47D cells, respectively. Additionally, Enpp/Carbonic anhydrase-IN-2 (0.58, 1.16 µM) induces apoptosis in a dose-dependent manner in K-562 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Enpp/Carbonic anhydraseIN2, Enpp/Carbonic anhydrase-IN-2, enpp, Carbonic Anhydrase, CarbonicAnhydrase, Apoptosis

Compound Identifiers

PubChem CID

155814656