Enpp-1-IN-19

SKU: orb2566314

Description

Enpp-1-IN-19 (compound 29f) is a potent, orally bioavailable ENPP1 inhibitor (IC50 = 68 nM) that suppresses cGAMP hydrolysis. It enhances STING signaling and type I interferon responses, improving anti-PD-1 therapy and tumor control in CT26 syngeneic mouse models while promoting protective immune memory against recurrence.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 2738583-25-8
• MW: 344.39
• Formula: C₁₆H₁₆N₄O₃S
• SMILES: C(C=1C=2C(C(=O)N(C)N1)=CC=CC2)C3=CC=C(NS(N)(=O)=O)C=C3
• Target: STING,PDE

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

157040072