Enpp-1-IN-14

SKU: orb1301158

Description

Enpp-1-IN-14 is a potent and selective small molecule inhibitor of ENPP1, demonstrating an IC50 of 32.38 nM against the recombinant human enzyme. This compound exhibits anti-tumor activity and serves as a valuable research tool for studying cancer biology and immunomodulation in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2687222-59-7
• MW: 403.88
• Purity: >99.99% (May vary between batches)
• Formula: C₁₅H₂₂ClN₅O₄S
• SMILES: Cl.COc1cc2ncnc(N3CCCN(CC3)S(N)(=O)=O)c2cc1OC
• Target: PDE
• Solubility: DMSO:3.33 mg/mL (8.25 mM)

Bioactivity

• In Vivo:
  Enpp-1-IN-14 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth in female C57BL/6 mice (4-6 weeks old) implanted subcutaneously with 2×10^5 MC38 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

enpp-1

Compound Identifiers

PubChem CID

156824020